Looking at the Week 5 FBS schedule, we have the over/under for the Wisconsin vs. USC game as the best bet on the card. See below for more suggestions on point spreads and totals, including parlay possibilities.

See computer predictions and insights for that game and more below.

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College Football Computer Picks – Best Spread Bets

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Pick: Alabama +3.5 vs. Georgia

• Matchup: Georgia Bulldogs at Alabama Crimson Tide
• Projected Winner & Margin: Alabama by 6.1 points
• Time: 7:30 PM ET
• Date: Sept. 28
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Duke +2.5 vs. North Carolina

• Matchup: North Carolina Tar Heels at Duke Blue Devils
• Projected Winner & Margin: Duke by 5.3 points
• Time: 4:00 PM ET
• Date: Sept. 28
• TV Channel: ESPN2
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Oklahoma -2.5 vs. Auburn

• Matchup: Oklahoma Sooners at Auburn Tigers
• Projected Winner & Margin: Oklahoma by 6.8 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Louisville +9.5 vs. Notre Dame

• Matchup: Louisville Cardinals at Notre Dame Fighting Irish
• Projected Winner & Margin: Notre Dame by 5.6 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: Peacock

Pick: USC -4.5 vs. Wisconsin

• Matchup: Wisconsin Badgers at USC Trojans
• Projected Winner & Margin: USC by 7.7 points
• Time: 3:30 PM ET
• Date: Sept. 28
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

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College Football Computer Picks – Best Total Bets

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